Ärzteinfos

Publikationen

Radtke S, Zolk O, Renner B, Paulides M, Zimmermann M, Möricke A, Stanulla M, Schrappe M, Langer T
Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity and outcome in childhood acute lymphoblastic leukemia.

Blood. 2013 May 7

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Nitz A, Kontopantelis E, Bielack S, Koscielniak E, Klingebiel T, Langer T, Paulides M
Prospective evaluation of cisplatin- and carboplatin-mediated ototoxicity in paediatric and adult soft tissue and osteosarcoma patients. 

Oncol Lett (2013) 5:311-315. Epub 2012 Oct 25.

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Mulder RL, Paulides M, Langer T, Kremer LC, van Dalen EC
Cyclophosphamide versus ifosfamide for paediatric and young adult bone and soft tissue sarcoma patients.

Cochrane Database Syst Rev (2012) Dec 12.

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Brackmann F, Dörr HG, Bartram CR, Hinderhofer K, Holter W, Langer T
Glucocorticoid withdrawal – heterozygous carriers of congenital adrenal hyperplasia at risk?

Klin Padiatr (2012) 224:392-3. Epub 2012 Aug 22.

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Brackmann F, Krumbholz M, Langer T, Rascher W, Holter W, Metzler M
Novel MLL2 Mutation in Kabuki Syndrome with Hypogammaglobulinemia and Severe Chronic Thrombopenia
.
J Pediatr Hematol  Oncol (2012) Oct 4.

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Brecht IB, Agaimy A, Besendörfer M, Carbon R, Thiel FC, Rompel O, Osinski D, Langer T,  Metzler M, Holter W
Malignant Peritoneal Mesothelioma in a 16-Year-Old Girl: Presentation of a Rare Disease.
 
Klin Padiatr (2012) 224:170-3.

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Nonnenmacher L, Langer T, Blessing H, Gabriel H, Buchwald HJ, Meneksedag C, Kohne E, Gencik M, Debatin KM, Cario H
Hereditary hyperferritinemia cataract syndrome: clinical, genetic, and laboratory findings in 5 families.

Klin Padiatr (2011) 223:346-51.

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Paulides M, Stöhr W, Laws HJ, Graf N, Lakomek M, Berthold F, Schmitt K, Niggli F, Jürgens H, Bielack S, Koscielniak E, Klingebiel T, Langer T
Antibody levels against tetanus and diphtheria after polychemotherapy for childhood sarcoma: A report from the Late Effects Surveillance System.

Vaccine (2011) 29:1565-1568.

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Paulides M, Stöhr W, Laws HJ, Graf N, Lakomek M, Berthold F, Schmitt K, Niggli F, Jürgens H, Bielack S, Koscielniak E, Klingebiel T, Langer T
Immunity against tetanus and diphtheria after childhood sarcoma treatment. 

Klin Padiatr. (2010) 222:196.

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Jung R, Jacobs U, Krumbholz M, Langer T, Keller T, De Lorenzo P, Valsecchi MG, van der Velden VH, Moericke A, Stanulla M, Teigler-Schlegel A, Panzer-Gruemayer ER, van Dongen JJ, Schrappe M, den Boer ML, Pieters R, Rascher W, Metzler M
Bimodal distribution of genomic MLL breakpoints in infant acute lymphoblastic leukemia treatment.

Leukemia (2010) 24:903-907.

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Rohrer TR, Langer T, Grabenbauer GG, Buchfelder M, Glowatzki M, Dorr HG
Growth Hormone Therapy and the Risk of Tumor Recurrence after Brain Tumor Treatment in Children.

J Pediatr Endocr Met
(2010) 23:935-943.

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Peeters J, Meitert J, Paulides M, Beck JD, Langer T
Late Effects Surveillance System after childhood cancer in Germany, Austria and parts of Switzerland – update 2009.

Strahlenther Onkol (2009) 1855-1857.

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Peeters J, Meitert J, Paulides M, Wiener A, Beck JD, Calaminus G, Langer T
Health-related quality of life in ALL-patients treated with chemotherapy only. A report from the Late Effects Surveillance System in Germany.

Klin Padiatr (2009) 221: 156-161.

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von Goessel H, Jacobs U, Semper S, Krumbholz M, Langer T, Keller T, Schrauder A,  van der Velden VH, van Dongen JJ, Harbott J, Panzer-Grümayer ER, Schrappe M, Rascher W, Metzler M
Cluster analysis of genomic ETV6-RUNX1 (TEL-AML1) fusion sites in childhood acute lymphoblastic leukemia.

Leukemia Res (2009) 33:1082-1088.

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Paulides M, Mergenthaler A, Peeters J, Beck JD, Langer T, Kaatsch P
Bedeutende organbezogene Langzeitfolgen von Chemotherapie und Zweitmalignomen.

Med Welt (2008) 59:105-109.  


Metzler M, Staege MS, Harder L, Mendelova D, Zuna J, Fronkova E, Meyer C, Flohr T, Bednarova D, Harbott J, Langer T, Gesk S, Trka J, Siebert R, Dingermann T, Marschalek R, Niemeyer C, Rascher W
Inv(11)(q21q23) fuses MLL to the Notch co-activator mastermind-like 2 in secondary T cell acute lymphoblastic leukemia.

Leukemia (2008) 22:1807-1811.

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Langer T, Deeg KH, Hümmer P, Paulides M, Beck JD, Klinge J
Postnatal respiratory distress in a dichorial twin with congenital thoracic neuroblastoma after assisted reproduction by intracytoplasmatic sperm injection.

Pediatr Blood Cancer (2007) 48:358-360.

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Bölling T, Schuck A, Pape H, Rübe C, Meyer FM, Martini C, Timmermann B, Asadpour  B, Kortmann RD, Beck JD, Langer T, Paulides M, Willich N
German register for detection of late sequelae after radiotherapy for children and adolescents (RiSK): present status and first results.

Strahlenther Onkol (2007) 183 Spec No 2:7-8.

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Bölling T, Schuck A, Pape H, Rübe C, Meyer FM, Martini C, Timmermann B, Asadpour  B, Kortmann RD, Beck JD, Langer T, Paulides M, Könemann S, Willich N
Register for the evaluation of side effects after radiation in childhood and adolescence – first results.

Klin Padiatr (2007) 219:139-145.

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Stöhr W, Paulides M, Bielack S, Jürgens H, Koscielniak E, Rossi R, Langer T, Beck JD
Nephrotoxicity of cisplatin and carboplatin in sarcoma patients: A report from the Late Effects Surveillance System.

Pediatr Blood Cancer (2007) 48:140-147.

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Stöhr W, Paulides M, Bielack S, Jürgens H, Treuner J, Rossi R, Langer T, Beck JD
Ifosfamide-induced Nephrotoxicity in 593 Sarcoma Patients: A Report from the Late Effects Surveillance System.

Pediatr Blood Cancer
(2007) 48:447-452.

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Stöhr W, Patzer L, Paulides M, Kremers A, Beck JD, Langer T, Rossi R
Growth Impairment after Ifosfamide-induced Nephrotoxicity in Children: A Report from the Late Effects Surveillance System.

Pediatr Blood Cancer (2007) 48:571-576.

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Deeg KH, Dachert C, Glockel U, Langer T
The Different Features of Congenital Neuroblastomas: Report about the Sonographic Diagnosis of Three Cases. 

Ultraschall Med. (2007) 28:313-320.

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Krappmann P, Paulides M, Stöhr W, Ittner E, Plattig B, Nickel P, Lackner H, Schrappe M,
Janka G, Beck JD, Langer T
Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: Results of an Austrian-German multicenter longitudinal study and implications for follow-up.

Pediatr Hematol Oncol. (2007) 24:101-109.

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Paulides M, Haupt R, Jankovic M, Moricke A, Langer T, Beck JD
Over 15 years of ELTEC: A report of the international BFM study group.

Pediatr Blood Cancer (2007) 49:113-114.

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Paulides M, Dörr HG, Stöhr W, Bielack S, Koscielniak E, Klingebiel T, Jürgens H, Bölling T, Willich N, Sauer R, Langer T, Beck JD
Thyreoid function in paediatric and young adult patients after sarcoma therapy: a report from the Late Effects Surveillance System.

Clin Endocrinol (Oxf). (2007) 66:727-731.

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Metzler M, Mann G, Monschein U, Lodzinski M, Gall C, Flohr T, Viehmann S, Langer T, Schrappe M, Gadner H, Haas OA, Panzer-Grumayer ER
Temporary blast reduction after immunoglobulin administration for congenital cytomegalovirus infection masking infant leukemia with cryptic MLL rearrangement
 
Leukemia Res (2007) 31:553-557.

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Rau T, Erney B, Göres R, Eschenhagen T, Beck J, Langer T
Association of an ABCC2 polymorphism with increased methotrexate plasma concentrations in pediatric patients with ALL.

Clin Pharmacol Ther (2006) 80:468-476.

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Bolling T, Schuck A, Rube C, Hesselmann S, Pape H, Dieckmann K, Pollinger B, Kortmann RD, Speiser-Held I, Meyer FM, MArtini C, Asadpour B, Timmermann B, Beck JD, Langer T, Paulides M, Schmidt B, Willich N
Therapy-associated late effects after irradiation of malignant diseases in childhood and adolescence. Feasibility analyses of a prospective multicenter register study.
Strahlenther Onkol (2006) 182:443-449.

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Metzler M, Mann G, Monschein U, Lodzinski M, Gall C, Flohr T, Viehmann S, Langer T, Schrappe M, Gadner H, Haas OA, Panzer-Grumayer ER
Minimal residual disease analysis in children with t(12;21)-positive acute lymphoblastic leukemia: comparison of Ig/TCR rearrangements and the genomic fusion gene.

Haematologica (2006) 91:683-686.

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Volkl TM, Langer T, Aigner T, Grees H, Beck JD, Rauch AM, Dorr HG
Klinefelder syndrome and mediastinal germ cell tumors.

Am J Med Genet A (2006) 140:471-481.

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Paulides M, Stohr W, Bielack S, Jurgens H, Koscielniak E, Klingebiel T, Zimmermann R, Stachel D, Langer T, Beck JD
Prospective evaluation of hepatitis B, C and HIV infections as possible sequelae of antineoplastic treatment in paediatric sarcoma patients: a report from the Late Effects Surveillance System.

Oncol Rep (2006) 15:687-691.

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Paulides M, Kremers A, Stöhr W, Bielack S, Jürgens H, Treuner J, Beck JD, Langer T
Prospective longitudinal evaluation of doxorubicin-induced cardiomyopathy in sarcoma patients: A report of the Late Effects Surveillance System (LESS).

Pediatr Blood Cancer (2006) 46:489-495.

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Stöhr W, Paulides M, Brecht I, Kremers A, Treuner J, Langer T, Beck JD
Comparison of epirubicin and doxorubicin cardiotoxicity in children and adolescents treated within the German Cooperative Soft Tissue Sarcoma Study (CWS).

J Cancer Res Clin (2006) 132:35-40.

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Langer T, Stöhr W, Paulides M, Kremers A, Göbel U, Beck JD
Prospective multicentre registration of major late sequelae in sarcoma patients using the Late Effects Surveillance System (LESS).

Klin Padiatr (2005) 217: 176-181.

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Stöhr W, Langer T, Kremers A, Bielack S, Lamprecht-Dinnesen A, Frey E, Beck JD
Cisplatin-induced ototoxicity in osteosarcoma patients: A report from the Late effects Surveillance System.

Cancer Invest (2005) 23:201-207.

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Schrappe M, Strehl S, Reiter A, Elsner H-A, Trka J, Cario G, Viehmann S, Harbott J, Borkhardt A, Metzler M, Langer T, Repp R, Marschalek R, Welte K, Haas OA, Stanulla M
NQO1 C609T polymorphism in distinct entities of pediatric hematologic neoplasms.

Haematologica (2004) 89: 1492-1497.

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Langer T, Stöhr W, Bielack S, Paulussen M, Treuner J, Beck JD
Late effects surveillance system for sarcoma patients.

Pediatr Blood Cancer (2004) 42:373-379.

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Metzler M, Niemeyer C, Meerpohl J, Ludwig WD, Reinhardt D, Viehmann S, Borkhardt A, Stanulla M, Schrappe M, Creutzig U, Ritter J, Harbott J, Beck JD, Rascher W, Repp R, Langer T
Emergence of translocation t
(9;11) positive leukemia during treatment of childhood acute lymphoblastic leukemia.
Genes Chromosomes Cancer (2004) 41:291-296.

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Metzler M, Brehm U, Langer T, Viehmann S, Borkhardt A, Stanulla M, Schrappe M, Harbott J, Beck JD, Rascher W, Repp R
Asymmetric multiplex-polymerase chain reaction – a high throughput method for detection and sequencing genomic fusion sites in t(4;11).

Brit J Haematol (2004) 124:47-54.

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Stöhr W, Langer T, Kremers A, Brecht I, Treuner J, Dinnesen A, Beck JD
Hearing function in soft tissue sarcoma patients after treatment with carboplatin: A report from the Late Effects Surveillance System.

Oncol Rep (2004) 12:767-771.

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Langer T, Beck JD, Gravou-Apostolatou Ch, Lang P, Handgretinger R, Greil J
Successful treatment of refractory acute myeloid leukemia with megadose stem cell transplantation, bone marrow boost and reduced intensity conditioning avoiding chronic graft vs. host disease and severe late toxicity.

Pediatr Transplant (2003) 7:494-496

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Langer T, Metzler M, Reinhardt D, Viehmann S, Borkhardt A, Reichel M, Stanulla M, Schrappe M, Creutzig U, Ritter J, Leis T, Jacobs U, Harbott J, Beck JD, Rascher W, Repp R
Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: Almost identical MLL breakpoints in therapy-related AML after treatment without etoposides.

Genes Chromosomes Cancer (2003) 36:393-401.

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Langer T, Martus P, Ottensmeier H, Hertzberg H, Beck JD, Meier W
CNS late-effects after ALL-therapy in childhood Part III: Neuropsychological performance in long-term survivors of childhood ALL. Impairments of distractibility, attention and memory and its interferences to CNS morphology.

Med Pediatr Oncol (2002) 38:320-328.

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Winkler von Mohrenfels U, Ittner E, Beck JD, Langer T
Behavior problems, emotional changes and physical complaints in children suffering from acute lymphoblastic leukemia (ALL) – indications for a psycho-oncological follow-up in pediatric oncology.

Prävention und Rehabilitation (2002) 14:129-137.


Jankovic M, Reciputo A, Haupt R, Micalizzi C, Manganini C, Frey E, Lackner H, Maurus R, Beck JD, Langer T, Marx M, Krappmann P, Magyarosy E, Feldges A, van Weel-Sipman M
ELTEC: ten years of activity (1990-2000) – a report of the International BFM Study Group.

Med Pediatr Oncol (2002) 38:124.

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Marx M, Langer T, Graf N, Hausdorf G, Stöhr W, Ludwig R, Beck JD
Multicentre analysis of anthracycline-induced cardiotoxicity in children following treatment according to the nephroblastoma studies SIOP no.9/GPOH and SIOP 93-01/GPOH.

Med Pediatr Oncol (2002) 39:18-24.

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Schroth M, Hertzberg H, Langer T, Beck JD
Congenital Langerhans cell histiocytosis with isolated skin involvement.

Med Pediatr Oncol (2001) 37:73-74.

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Marx M, Beck JD, Müller HL, Kühl J, Langer T, Dörr HG
Endocrine late-effects of brain tumour therapy in childhood and adolescence: concept of a prospective endocrinological follow-up.

Klin Padiatr (2000) 212:224-228.                                                                                   


Langer T, Henze G, Beck JD
Basic methods and the developing structure of a late effects surveillance system (LESS) in the long-term follow-up of pediatric cancer patients in Germany. For the German Late Effects Study Group in the German Society Pediatric Oncology and Hematology (GPOH).

Med Pediatr Oncol (2000) 34:348-351.

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Marx M, Langer T, Beck JD, Dorr HG
Disorders of endocrine function after brain tumor therapy in childhood.

Strahlenther Onkol (1999)175:305-308.

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Langer T, Huk WJ, Hertzberg H, Überall MA, Meier W, Korinthenberg R, Beck JD
Akute lymphoblastische Leukämie im Kindesalter: Morphe und Funktion des Gehirns nach Behandlungsende.

Deutsches Ärzteblatt (1998) 3058-3068.


Beck JD, Hertzberg H, Kochendörfer S, Meier W , Göbel U, Greil J, Langer T
Neuropsychologische Spätfolgen nach Behandlung einer akuten lymphoblastischen Leukämie im Kindesalter.

Klin Onkol (1997) 11-15.
 


Hertzberg H, Huk WJ, Ueberall MA, Langer T, Meier W, Dopfer R, Skalej M, Lackner H, Bode U, Janssen G, Zintl F, Beck JD
CNS late effects after ALL therapy in childhood.
Part I: Neuroradiological findings in long-term survivors of childhood ALL – an evaluation of the interferences between morphology and neuropsychological performance. The German Late Effects Working Group.
Med Pediatr Oncol (1997) 28:387-400.

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Überall MA; Wenzel D; Hertzberg H; Langer T; Meier W; Berger-Jones K; Huk WJ; Neuhäuser G; Lampert F; Beck JD; Korinthenberg R
CNS late-effects after ALL therapy in childhood Part II: Conventional EEG recordings in asymptomatic long-term survivors of childhood ALL. An evaluation of the interferences between neurophysiology, neurology, psychology and CNS morphology.

Med Pediatr Oncol (1997) 29:121-131.

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Überall MA, Skirl G, Strassburg HM, Wenzel D, Hertzberg H, Langer T, Meier W, Berger-Jones K, Huk WJ, Korinthenberg R, Beck JD
Neurophysiological findings in long-term survivors of acute lymphoblastic leukaemia in childhood treated with the BFM protocol 81 SR-A/B.

Eur J Pediatr (1997) 156:727-733.

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Überall MA, Haupt K, Hertzberg H, Langer T, Meier W, Huk WJ, Beck JD, Wenzel D
Quantitative EEG in long-term survivors of acute lymphoblastic leukemia.

Pediatr Neurol (1996) 15: 293-298.
                                                                               

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Überall MA, Hertzberg H, Meier W, Langer T, Beck JD, Wenzel D
Visual-evoked potentials in long-term survivors of acute lymphoblastic leukemia in childhood. The German Late Effects Working Group.

Neuropediatrics (1996) 27:194-196.

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